Looking for a drug cure for Chronic Fatigue Syndrome is a bit like trying to buy a new Buick from a Ford dealer: it just isn't possible. The first rule of fishing is to put your hook in the water, because that is where the fish are. Let's consider nutrition research and see what REAL options are available for the CFIDS patient that has been told to "learn to live with it."
Generally speaking, the dictionary defines fatigue with equally incomplete substitutes such as tiredness, lassitude, weakness, exhaustion, ennui, burnout and/or boredom. Some few larger lexicons go beyond this synonym chanting. When they do, fatigue and energy are somehow related. As energy goes down ... fatigue goes up!